How to Cite
RS, G., & Singh, B. (1). Heredity and Otosclerosis: A Review. Journal of All India Institute of Speech and Hearing, 14(1), 113-122. Retrieved from http://203.129.241.91/jaiish/index.php/aiish/article/view/796
Abstract
A genealogical tree is presented of a family in which the dominant heredity of clinical otosclerosis was traced through three generations. Recent hypotheses for hereditary transmission of the disease have been advanced and evaluated. Chromosomal changes in otosclerotic subjects have been found by different workers to be conspicuously absent. Therefore the most convenient, and practical, way of ascertaining the exact mode of genetic ransmission in otosclerosis is through large-scale family studies. This particularly holds good for a vast country like India. The most recent genetic studies in the field indicate a polygenic and probably multifactorial mode of heredity of otosclerosis.
References
CADA, K. and SOUDEK, D. (1968): "Chromosomal examination in otoscle- rosis and the syndrome of van den Hoeve de Kleyn" Cesk. Otola- ryngol, 17, pp. 285-287 (English Abstract).
CAUSSE, J. R. and CAUSSE , J B. (1980): "Otospongiosis, a genetic disease.
Its early detection. Its medical management" Ann. Otolaryngol et
Chir. Cervicofac, 97, pp. 325-351 (English Abstract).
CHUMLEA, B. J. (1942) : "A pedigree of otosclerosis" J. Hered., 33, pp. 98-99.
DAVENPORT, C. B., MILLES, B. L. and FRlNK, L. B. (1933 a,b c) : "Th e
genetic factor in otosclerosis" Arch. Otolaryngol., 17, Part I. pp. 135-
170 ; 17, Part II, pp. 340-383 ; 17, Part III, pp. 503 548.
FALCONER. D. S. (1972) : "Introduction to Quantitative Genetics,". Edinburgh, Oliver and Boyd, Ch. 8, pp. 129-149.
FOWLER, E. P. (1963): "Diseases of the Nose, Throat and Ear". Editors Jackson, C. and Jackson, C. L. Philadelphia, W. B. Saunders Com- pany, Part III, p. 485.
GAPANAVICHYUS, B. M. (1971): "The role of the hereditary factor in the etiology of otosclerosis" Vestn. Otorinolaringol., 33, pp. 9-15 (English Abstract)
GUKOVICH, V. A. (1969) : "On the role of heredity in the development of otosclerosis" Zh. Ushn., Nos. Gorl. Boleznei, 29, pp. 72-77 (English
Abstract).
GUKOVICH, V. A. (1976) : "Clinical genetics of otosclerosis" Zh. Ushn. Nos.
Gorl Boleznei, 2, pp. 1-6 and 5, pp. 7-10 (English Abstract).
GUKOVICH, V A. (1977) : "Characteristics of otosclerosis in close relatives"
Vestn. Otorinolaringol, 1, pp. 9-15 (bnglish Abstract).
HERNANDEZ - OROZCO, F. and COURTNEY, G. T (1964): "Genetic aspects of clinical otosclerosis" Ann. Otol. Rhinol. Laryngol,, 73, pp.
632-644.
KABAT, C. (1943) : "A family history of deafness" / Hered., 34. pp. 377-378. KHOLMATOV, I. B. (1973): "Some problems in studying heredi'y in otos-
cerosis" Vestn. Otorinolaringol., 35, pp. 51-56(English Abstract).
KOGA, K., SUZUKI. Y., SAKA1, M. aid MUKAI, M. (1974) : "Familial otosclerosis with chromosomal aberration" Jap J, Human Genetics, 19, pp. 85-86 (English Translation).
LARSSON.A. (1960): "Otosclerosis. A genetic and clinical study" Acta
Otolaryngol. (Suppl,), 154, pp. 1-86. -
LINDSAY,J.R.(1973) : "Otolaryngology". Editors: Paprella, MM and Shumrick, D. A. Philadelphia, W.B. Saunders Company, Vol II, Ch.14, p.207.
MARINELLI, C. and MARMO, F. (1968) : "A familial otosclerotic nucleus followed for four generations. Genetic considerations" Arch. Ital. Laringol, 16, pp. 301-308 (English Abstract).
MARTIN.J.P, and CHEVANCE, L G. (1976): "The genetics of the pro- tease inhibitor system and otospongiosis. Statistical study in 199 patrents" Ann. Otolaryngol.et Chir. Cervicofac, 93, pp. 733-736 (Eng- lish Abstract) .
McKUSICK.VA . (1972) : "Human Genetics". Editors : Suskind, S.R. an d Hartman , P.E. New Delhi , Prentice-Hal l of Tndia Privat e Ltd., Ch.6 , pp . 154-159.
MENDLOWITZ.J.C . and H1RSCHHORN, K- (1976): "Polygenic inheritance of otosclerosis" Ann. Otol. Rhinol. Laryngol, 85, pp . 281-285.
MORRISON,A.W. (1967): "Genetic factors in otosclerosis" Ann. Roy.
Coll. Surg. Engl, 41, pp. 202-232.
MORRISON.A,W. (1971): "Diseases of the Ear, Nose and Throat" Editors : Ballantyne, J. and Grovers, J. London, Butterworths, Vol. II, Ch. 13, pp.359-360.
MUKHERJEE,A,L- (1976): "A study on genetics and otosclerosis" Indian
J. Otolaryngol., 28, p. 133.
MUKHERJEE, A.L. (1982): Personal communication.
NITZE,H R (1967): "Chromosomal research on otosclerosis" Arch. Klin- Exper. Ohren- Nasen-und Kehlkopfheilk, 189, pp.187-194 (English Abs- tract).
PFANDLER, U, (1949): "The heredity of otosclerosis" Schweiz. Med. Woch-
enschr., 79, pp. 692-700.
RUEDI.L. (1963): "Pathogenesis of otosclerosis" Arch. Otolaryngol, 78, pp. 469 477.
SHAMBAUGH.C.E. and PETROVIC,A. (1968): "Effects of sodium fluoride :on tone. Application to otosclerosis and other decalcifying bone diseases" (Special communication) JAMA, 204, pp. 969-973.
TATO,J.M., de LOZZlO, C.B. and VALENCIA, J.J. (1963): "Chromosomal study in otosclerosis" Acta Otolaryngol., 56, pp. 265-270.
TINKLE.W.J. (1933): "Deafness as a eugenical p.oblem" J. Hered., 24, pp.13-18.
TOYNBEEJ. (1961): "Pathological and surgical observations on diseases of the ear" Medico-Chirurgical Transactions, 24, p. 190.
VOYACHEK.V.I (1925): "Heredity of certain otolaryngological diseases"
Zh. Ushn., Nos Gorl Boleznei, 7, p. 331 (English Translation).
CAUSSE, J. R. and CAUSSE , J B. (1980): "Otospongiosis, a genetic disease.
Its early detection. Its medical management" Ann. Otolaryngol et
Chir. Cervicofac, 97, pp. 325-351 (English Abstract).
CHUMLEA, B. J. (1942) : "A pedigree of otosclerosis" J. Hered., 33, pp. 98-99.
DAVENPORT, C. B., MILLES, B. L. and FRlNK, L. B. (1933 a,b c) : "Th e
genetic factor in otosclerosis" Arch. Otolaryngol., 17, Part I. pp. 135-
170 ; 17, Part II, pp. 340-383 ; 17, Part III, pp. 503 548.
FALCONER. D. S. (1972) : "Introduction to Quantitative Genetics,". Edinburgh, Oliver and Boyd, Ch. 8, pp. 129-149.
FOWLER, E. P. (1963): "Diseases of the Nose, Throat and Ear". Editors Jackson, C. and Jackson, C. L. Philadelphia, W. B. Saunders Com- pany, Part III, p. 485.
GAPANAVICHYUS, B. M. (1971): "The role of the hereditary factor in the etiology of otosclerosis" Vestn. Otorinolaringol., 33, pp. 9-15 (English Abstract)
GUKOVICH, V. A. (1969) : "On the role of heredity in the development of otosclerosis" Zh. Ushn., Nos. Gorl. Boleznei, 29, pp. 72-77 (English
Abstract).
GUKOVICH, V. A. (1976) : "Clinical genetics of otosclerosis" Zh. Ushn. Nos.
Gorl Boleznei, 2, pp. 1-6 and 5, pp. 7-10 (English Abstract).
GUKOVICH, V A. (1977) : "Characteristics of otosclerosis in close relatives"
Vestn. Otorinolaringol, 1, pp. 9-15 (bnglish Abstract).
HERNANDEZ - OROZCO, F. and COURTNEY, G. T (1964): "Genetic aspects of clinical otosclerosis" Ann. Otol. Rhinol. Laryngol,, 73, pp.
632-644.
KABAT, C. (1943) : "A family history of deafness" / Hered., 34. pp. 377-378. KHOLMATOV, I. B. (1973): "Some problems in studying heredi'y in otos-
cerosis" Vestn. Otorinolaringol., 35, pp. 51-56(English Abstract).
KOGA, K., SUZUKI. Y., SAKA1, M. aid MUKAI, M. (1974) : "Familial otosclerosis with chromosomal aberration" Jap J, Human Genetics, 19, pp. 85-86 (English Translation).
LARSSON.A. (1960): "Otosclerosis. A genetic and clinical study" Acta
Otolaryngol. (Suppl,), 154, pp. 1-86. -
LINDSAY,J.R.(1973) : "Otolaryngology". Editors: Paprella, MM and Shumrick, D. A. Philadelphia, W.B. Saunders Company, Vol II, Ch.14, p.207.
MARINELLI, C. and MARMO, F. (1968) : "A familial otosclerotic nucleus followed for four generations. Genetic considerations" Arch. Ital. Laringol, 16, pp. 301-308 (English Abstract).
MARTIN.J.P, and CHEVANCE, L G. (1976): "The genetics of the pro- tease inhibitor system and otospongiosis. Statistical study in 199 patrents" Ann. Otolaryngol.et Chir. Cervicofac, 93, pp. 733-736 (Eng- lish Abstract) .
McKUSICK.VA . (1972) : "Human Genetics". Editors : Suskind, S.R. an d Hartman , P.E. New Delhi , Prentice-Hal l of Tndia Privat e Ltd., Ch.6 , pp . 154-159.
MENDLOWITZ.J.C . and H1RSCHHORN, K- (1976): "Polygenic inheritance of otosclerosis" Ann. Otol. Rhinol. Laryngol, 85, pp . 281-285.
MORRISON,A.W. (1967): "Genetic factors in otosclerosis" Ann. Roy.
Coll. Surg. Engl, 41, pp. 202-232.
MORRISON.A,W. (1971): "Diseases of the Ear, Nose and Throat" Editors : Ballantyne, J. and Grovers, J. London, Butterworths, Vol. II, Ch. 13, pp.359-360.
MUKHERJEE,A,L- (1976): "A study on genetics and otosclerosis" Indian
J. Otolaryngol., 28, p. 133.
MUKHERJEE, A.L. (1982): Personal communication.
NITZE,H R (1967): "Chromosomal research on otosclerosis" Arch. Klin- Exper. Ohren- Nasen-und Kehlkopfheilk, 189, pp.187-194 (English Abs- tract).
PFANDLER, U, (1949): "The heredity of otosclerosis" Schweiz. Med. Woch-
enschr., 79, pp. 692-700.
RUEDI.L. (1963): "Pathogenesis of otosclerosis" Arch. Otolaryngol, 78, pp. 469 477.
SHAMBAUGH.C.E. and PETROVIC,A. (1968): "Effects of sodium fluoride :on tone. Application to otosclerosis and other decalcifying bone diseases" (Special communication) JAMA, 204, pp. 969-973.
TATO,J.M., de LOZZlO, C.B. and VALENCIA, J.J. (1963): "Chromosomal study in otosclerosis" Acta Otolaryngol., 56, pp. 265-270.
TINKLE.W.J. (1933): "Deafness as a eugenical p.oblem" J. Hered., 24, pp.13-18.
TOYNBEEJ. (1961): "Pathological and surgical observations on diseases of the ear" Medico-Chirurgical Transactions, 24, p. 190.
VOYACHEK.V.I (1925): "Heredity of certain otolaryngological diseases"
Zh. Ushn., Nos Gorl Boleznei, 7, p. 331 (English Translation).