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http://localhost:8080//handle/123456789/2146
Title: | Genetics in Stuttering |
Authors: | Ram, Anjana B Savithri, S R |
Issue Date: | 2008 |
Journal Name: | Student Research at AIISH-2003-2004 |
Volume No.: | 2 |
Pages: | 121-129 |
Abstract: | This study investigated the role of genetics in the manifestation of stuttering. Thirty families were investigated. Twenty-eight families reported history of stuttering in first and second degree relatives. Two twin samples were taken, one comprising of monozygotic twins and the other dizygotic twins. Pedigrees were constructed and analyzed to determine the pattern of genetic transmission. Speech samples of the probands were recorded and percent dys fluency was analysed. The results indicated that the risk of .stuttering was greater in close/first degree relatives (54.5%) compared to second-degree relatives (45.4%). Also, stuttering among relatives occured in a pattern indicating vertical transmission of a susceptibility to stutter with sex-modified expression. There was greater concordance for the disorder among monozygotic than among dizygotic twins. In families with positive family history for stuttering, males (88) was genetically more susceptible to stuttering than females (9) (9. 7: I). There was no correlation between consanguinity and genetic transmission of stuttering. The proportion of persistent stutters (19%) among relatives of male probands was higher than the proportion of recovered stutterers (2.3%). Stuttering if familial tends to be of relatively early and gradual onset. Stuttering severity and familial stuttering don't seem to have any relationship. The results are discussed to fit into the single-Locus model and multi factorial model. |
URI: | http://203.129.241.91:8080//handle/123456789/2146 |
Appears in Resource: | Journal Articles |
File | Description | Size | Format | |
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Genetics in Stuttering.pdf | 4.47 MB | Adobe PDF | View/Open |
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